Without ADH, the concentration of filtrate actually DECREASES as it progresses along the collecting duct. This is due to ENaC channels in the principal cells along the collecting duct, which are able to reabsorb some sodium. For more videos and questions, visit -
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The filtrate can reach a concentration as low as 50 mOsm/L. In the absence of ADH, the medullary concentration gradient is only 600 mOsm/L because there are no urea channels.
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